Just thought I would make a post here in case anyone else came across this problem since I have found the solution that worked for me that wasn’t posted anywhere else.
I am using Reaper 4.22 on Windows 10 Pro 64 bit.
Originally I had Python installed on a different HDD than my main “C:” drive as well as I had 2.7.11 installed.
What seemed to work for me is installing 2.7.12 as well as keeping Python installed on the main “C:” drive. After that, everything worked great.
Hopefully this helps anyone that has this problem in the future.